Synchronously waiting for an async operation, and why does Wait() freeze the program here

The await inside your asynchronous method is trying to come back to the UI thread.

Since the UI thread is busy waiting for the entire task to complete, you have a deadlock.

Moving the async call to Task.Run() solves the issue.
Because the async call is now running on a thread pool thread, it doesn't try to come back to the UI thread, and everything therefore works.

Alternatively, you could call StartAsTask().ConfigureAwait(false) before awaiting the inner operation to make it come back to the thread pool rather than the UI thread, avoiding the deadlock entirely.

Calling async code from synchronous code can be quite tricky.

I explain the full reasons for this deadlock on my blog. In short, there's a "context" that is saved by default at the beginning of each await and used to resume the method.

So if this is called in an UI context, when the await completes, the async method tries to re-enter that context to continue executing. Unfortunately, code using Wait (or Result) will block a thread in that context, so the async method cannot complete.

The guidelines to avoid this are:

Use ConfigureAwait(continueOnCapturedContext: false) as much as possible. This enables your async methods to continue executing without having to re-enter the context. Use async all the way. Use await instead of Result or Wait.

If your method is naturally asynchronous, then you (probably) shouldn't expose a synchronous wrapper.

Here is what I did

private void myEvent_Handler(object sender, SomeEvent e)
{
  // I dont know how many times this event will fire
  Task t = new Task(() =>
  {
    if (something == true) 
    {
        DoSomething(e);  
    }
  });
  t.RunSynchronously();
}

working great and not blocking UI thread

With small custom synchronization context, sync function can wait for completion of async function, without creating deadlock. Here is small example for WinForms app.

Imports System.Threading
Imports System.Runtime.CompilerServices

Public Class Form1

    Private Sub Form1_Load(sender As Object, e As EventArgs) Handles MyBase.Load
        SyncMethod()
    End Sub

    ' waiting inside Sync method for finishing async method
    Public Sub SyncMethod()
        Dim sc As New SC
        sc.WaitForTask(AsyncMethod())
        sc.Release()
    End Sub

    Public Async Function AsyncMethod() As Task(Of Boolean)
        Await Task.Delay(1000)
        Return True
    End Function

End Class

Public Class SC
    Inherits SynchronizationContext

    Dim OldContext As SynchronizationContext
    Dim ContextThread As Thread

    Sub New()
        OldContext = SynchronizationContext.Current
        ContextThread = Thread.CurrentThread
        SynchronizationContext.SetSynchronizationContext(Me)
    End Sub

    Dim DataAcquired As New Object
    Dim WorkWaitingCount As Long = 0
    Dim ExtProc As SendOrPostCallback
    Dim ExtProcArg As Object

    <MethodImpl(MethodImplOptions.Synchronized)>
    Public Overrides Sub Post(d As SendOrPostCallback, state As Object)
        Interlocked.Increment(WorkWaitingCount)
        Monitor.Enter(DataAcquired)
        ExtProc = d
        ExtProcArg = state
        AwakeThread()
        Monitor.Wait(DataAcquired)
        Monitor.Exit(DataAcquired)
    End Sub

    Dim ThreadSleep As Long = 0

    Private Sub AwakeThread()
        If Interlocked.Read(ThreadSleep) > 0 Then ContextThread.Resume()
    End Sub

    Public Sub WaitForTask(Tsk As Task)
        Dim aw = Tsk.GetAwaiter

        If aw.IsCompleted Then Exit Sub

        While Interlocked.Read(WorkWaitingCount) > 0 Or aw.IsCompleted = False
            If Interlocked.Read(WorkWaitingCount) = 0 Then
                Interlocked.Increment(ThreadSleep)
                ContextThread.Suspend()
                Interlocked.Decrement(ThreadSleep)
            Else
                Interlocked.Decrement(WorkWaitingCount)
                Monitor.Enter(DataAcquired)
                Dim Proc = ExtProc
                Dim ProcArg = ExtProcArg
                Monitor.Pulse(DataAcquired)
                Monitor.Exit(DataAcquired)
                Proc(ProcArg)
            End If
        End While

    End Sub

     Public Sub Release()
         SynchronizationContext.SetSynchronizationContext(OldContext)
     End Sub

End Class

For me actually the best working solution:

AsyncMethod(<params>).ConfigureAwait(true).GetAwaiter().GetResult();

Works also on UI-Content without blocking and dispatcher problems, and also from CTOR's.