HTTP Error 500.22 - Internal Server Error (An ASP.NET setting has been detected that does not apply in Integrated managed pipeline mode.)

This issue is caused by the pipeline mode in your Application Pool setting that your web site is set to.

Short

Simple way Change the Application Pool mode to one that has Classic pipeline enabled.

Correct way Your web.config / web app will need to be altered to support Integrated pipelines. Normally this is as simple as removing parts of your web.config.

Simple way (bad practice) Add the following to your web.config. See http://www.iis.net/ConfigReference/system.webServer/validation

Long If possible, your best bet is to change your application to support the integrated pipelines. There are a number of changes between IIS6 and IIS7.x that will cause this error. You can find details about these changes here http://learn.iis.net/page.aspx/381/aspnet-20-breaking-changes-on-iis-70/.

If you're unable to do that, you'll need to change the App pool which may be more difficult to do depending on your availability to the web server.

Go to the web server

Open the IIS Manager

Navigate to your site

Click Advanced Settings on the right Action pane

Under Application Pool, change it to an app pool that has classic enabled.

Check http://technet.microsoft.com/en-us/library/cc731755(WS.10).aspx for details on changing the App Pool

If you need to create an App Pool with Classic pipelines, take a look at http://technet.microsoft.com/en-us/library/cc731784(WS.10).aspx

If you don't have access to the server to make this change, you'll need to do this through your hosting server and contact them for help.

Feel free to ask questions.

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In your web.config, make sure these keys exist:

<configuration>
    <system.webServer>
        <validation validateIntegratedModeConfiguration="false"/>
    </system.webServer>
</configuration>

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I changed my web.config file to use HTTPMODULE in two forms:

IIS: 6

<httpModules>
    <add name="Module" type="app.Module,app"/>
</httpModules>

IIS: 7.5

<system.webServer>
    <modules>
       <add name="Module" type="app.Module,app"/>
    </modules>
</system.webServer>

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Using VS2013 .net 4.5

I had this same issue.

The "Most likely causes" section on the error message page provided the most help. For me. It said "This application defines configuration in the system.web/httpModules section." Then in the "Things you can try" section it said "Migrate the configuration to the system.webServer/modules section."

<system.web>
      <httpHandlers>
        <add type="DevExpress.Web.ASPxUploadProgressHttpHandler, DevExpress.Web.v15.1, Version=15.1.4.0, Culture=neutral, PublicKeyToken=b88d1754d700e49a" verb="GET,POST" path="ASPxUploadProgressHandlerPage.ashx" validate="false" />
        <add type="DevExpress.Web.ASPxHttpHandlerModule, DevExpress.Web.v15.1, Version=15.1.4.0, Culture=neutral, PublicKeyToken=b88d1754d700e49a" verb="GET" path="DX.ashx" validate="false" />
      </httpHandlers>
      <httpModules>
        <add type="DevExpress.Web.ASPxHttpHandlerModule, DevExpress.Web.v15.1, Version=15.1.4.0, Culture=neutral, PublicKeyToken=b88d1754d700e49a" name="ASPxHttpHandlerModule" />
      </httpModules>
    </system.web>

into the system.webServer section.

<system.webServer> 
    <handlers>
      <add type="DevExpress.Web.ASPxUploadProgressHttpHandler, DevExpress.Web.v15.1, Version=15.1.4.0, Culture=neutral, PublicKeyToken=b88d1754d700e49a" verb="GET,POST" path="ASPxUploadProgressHandlerPage.ashx" name="ASPxUploadProgressHandler" preCondition="integratedMode" />
      <add type="DevExpress.Web.ASPxHttpHandlerModule, DevExpress.Web.v15.1, Version=15.1.4.0, Culture=neutral, PublicKeyToken=b88d1754d700e49a" verb="GET" path="DX.ashx" name="ASPxHttpHandlerModule" preCondition="integratedMode" />
    </handlers>
    <modules>
      <add type="DevExpress.Web.ASPxHttpHandlerModule, DevExpress.Web.v15.1, Version=15.1.4.0, Culture=neutral, PublicKeyToken=b88d1754d700e49a" name="ASPxHttpHandlerModule" />
    </modules>
</system.webServer>

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This worked for me:

Delete the originally created site. Recreate the site in IIS Clean solution Build solution

Seems like something went south when I originally created the site. I hate solutions that are similar to "Restart your machine, then reinstall windows" without knowing what caused the error. But, this worked for me. Quick and simple. Hope it helps someone else.

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I have a similar problem with IIS 7, Win 7 Enterprise Pack. I have changed the application Pool as in @Kirk answer :

Change the Application Pool mode to one that has Classic pipeline enabled".but no luck for me.

Adding one more step worked for me. I have changed the my website's .NET Frameworkis v2.0 to .NET Frameworkis v4.0. in ApplicationPool

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Personnaly I encountered this issue while migrating a IIS6 website into IIS7, in order to fix this issue I used this command line :
%windir%\System32\inetsrv\appcmd migrate config "MyWebSite\"
Make sure to backup your web.config

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Set Application pool to classic .NET appool and make sure that Classic .Net apppool working on Classic managed piple line .

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