Can I delete data from the iOS DeviceSupport directory?

The ~/Library/Developer/Xcode/iOS DeviceSupport folder is basically only needed to symbolicate crash logs.

You could completely purge the entire folder. Of course the next time you connect one of your devices, Xcode would redownload the symbol data from the device.

I clean out that folder once a year or so by deleting folders for versions of iOS I no longer support or expect to ever have to symbolicate a crash log for.

More Suggestive answer supporting rmaddy's answer as our primary purpose is to delete unnecessary file and folder:

Delete this folder after every few days interval. Most of the time, it occupy huge space! ~/Library/Developer/Xcode/DerivedData All your targets are kept in the archived form in Archives folder. Before you decide to delete contents of this folder, here is a warning - if you want to be able to debug deployed versions of your App, you shouldn’t delete the archives. Xcode will manage of archives and creates new file when new build is archived. ~/Library/Developer/Xcode/Archives iOS Device Support folder creates a subfolder with the device version as an identifier when you attach the device. Most of the time it’s just old stuff. Keep the latest version and rest of them can be deleted (if you don’t have an app that runs on 5.1.1, there’s no reason to keep the 5.1.1 directory/directories). If you really don't need these, delete. But we should keep a few although we test app from device mostly. ~/Library/Developer/Xcode/iOS DeviceSupport Core Simulator folder is familiar for many Xcode users. It’s simulator’s territory; that's where it stores app data. It’s obvious that you can toss the older version simulator folder/folders if you no longer support your apps for those versions. As it is user data, no big issue if you delete it completely but it’s safer to use ‘Reset Content and Settings’ option from the menu to delete all of your app data in a Simulator. ~/Library/Developer/CoreSimulator

(Here's a handy shell command for step 5: xcrun simctl delete unavailable )

Caches are always safe to delete since they will be recreated as necessary. This isn’t a directory; it’s a file of kind Xcode Project. Delete away! ~/Library/Caches/com.apple.dt.Xcode Additionally, Apple iOS device automatically syncs specific files and settings to your Mac every time they are connected to your Mac machine. To be on safe side, it’s wise to use Devices pane of iTunes preferences to delete older backups; you should be retaining your most recent back-ups off course. ~/Library/Application Support/MobileSync/Backup

Source: https://ajithrnayak.com/post/95441624221/xcode-users-can-free-up-space-on-your-mac

I got back about 40GB!

I wrote a small command-line utility based on the great answer by @JamshedAlam for those who are tired of deleting the contents of those folders manually. Check it out here if you think it would help you.

Yes, you can delete data from iOS device support by the symbols of the operating system, one for each version for each architecture. It's used for debugging. If you don't need to support those devices any more, you can delete the directory without ill effect